one-pot and one-step novel n-methylation of 2,6-diaminopyridine

One-pot and one-step novel N-methylation of 2,6-diaminopyridine

2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't...

One-pot one-step deracemization of amines using ω-transaminases.

In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.

A Novel One-Pot and One-Step Microwave-Assisted Cyclization-Methylation Reaction of Amino Alcohols and Acetylated Derivatives with Dimethyl Carbonate and TBAC

A simple and efficient microwave-assisted methodology for the synthesis of 4-substituted-3-methyl-1,3-oxazolidin-2-ones from amino alcohols catalyzed by a ionic liquid was developed. This novel one-pot and one-step cyclization-methylation reaction represents an easier and faster method than any other reported protocols that can be used to obtain the desired products in good yields and high puri...

One-pot preparation of N,N′-alkylidenebisamides promoted by BF3.SiO2

A highly efficient procedure for the preparation of N,N'-alkylidenebisamides in the presence of BF3.SiO2 as a catalyst is described. N,N'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.

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One-pot preparation of N,N′-alkylidenebisamides promoted by BF3.SiO2

A highly efficient procedure for the preparation of N,N'-alkylidenebisamides in the presence of BF3.SiO2 as a catalyst is described. N,N'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.