one-pot and one-step novel n-methylation of 2,6-diaminopyridine
نویسندگان
چکیده
2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. it is soluble in protic solvents. primary and secondary amines are n-methylated by various methods such as direct alkylation of amines with hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. consequently, they aren't selective in secondary amines preparation. also, the selective synthesis of secondary amines is a problematic field in organic chemistry. 2,6-diaminopyridine can be selective n-methylated from reaction of this compound with sodium azide and orthoformic ester in low time with good yields.
منابع مشابه
One-pot and one-step novel N-methylation of 2,6-diaminopyridine
2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't...
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عنوان ژورنال:
iranian chemical communicationناشر: payame noor university (pnu)
ISSN 2423-4958
دوره 2
شماره Issue 3 (pp. 162-231) 2014
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